Journal article
Reproductive risk factors and oestrogen/progesterone receptor-negative breast cancer in the Breast Cancer Family Registry
ME Work, EM John, IL Andrulis, JA Knight, Y Liao, AM Mulligan, MC Southey, GG Giles, GS Dite, C Apicella, H Hibshoosh, JL Hopper, MB Terry
British Journal of Cancer | Published : 2014
DOI: 10.1038/bjc.2013.807
Abstract
Background:Oestrogen receptor (ER)- and progesterone receptor (PR)-negative (ER-PR-) breast cancer is associated with poorer prognosis compared with other breast cancer subtypes. High parity has been associated with an increased risk of ER-PR- cancer, but emerging evidence suggests that breastfeeding may reduce this risk. Whether this potential breastfeeding benefit extends to women at high risk of breast cancer remains critical to understand for prevention.Methods: Using population-based ascertained cases (n=4011) and controls (2997) from the Breast Cancer Family Registry, we examined reproductive risk factors in relation to ER and PR status.Results:High parity (≥3 live births) without brea..
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Awarded by National Institutes of Health
Funding Acknowledgements
This study was supported through the National Cancer Institute, National Institutes of Health under RFA-CA-06-503, UM1 CA164920, Cancer Care Ontario (U01 CA69467), Cancer Prevention Institute of California (U01 CA694117), University of Melbourne (U01 CA69638) and through cooperative agreements with members of the Breast Cancer Family Registry (BCFR) and Principal Investigators. The Australian Breast Cancer Family Study was also supported by the National Health and Medical Research Council of Australia, the New South Wales Cancer Council and the Victorian Health Promotion Foundation. The recruitment of controls by the Northern California Cancer Center was supported in part by National Institutes of Health Grant U01CA 71966. The recruitment of controls in Ontario was supported by the Canadian Breast Cancer Research Initiative. Funding for MEW was supported by a training grant from the National Cancer Institute, National Institutes of Health (T32 CA009529) and a training grant from the National Center for Advancing Translational Sciences, National Institutes of Health (TL1 TR00008), formerly the National Center for Research Resources (TL1 RR024158). The content of this manuscript does not necessarily reflect the views or policies of the National Cancer Institute or any of the collaborating centers in the BCFR, nor does mention of trade names, commercial products, or organisations imply endorsement by the US Government or the BCFR.